Review



recombinant mouse serum amyloid a2 protein saa2  (R&D Systems)


Bioz Verified Symbol R&D Systems is a verified supplier
Bioz Manufacturer Symbol R&D Systems manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 93
      Buy from Supplier

    Structured Review

    R&D Systems recombinant mouse serum amyloid a2 protein saa2
    Fig. 4. Vaccarin regulates <t>SAA2</t> expression through JNK inhibition, reversing IL-1β-induced chondrocyte senescence and inflammation. (A-D) Western blot analysis showing that SP600125 treatment reversed IL-1β-induced inflammation and senescence in chondrocytes, while exogenous SAA2 protein exacerbates these effects and reduced SP600125’s inhibitory effects. (E, F) Western blot confirmed that Vaccarin reduced IL-1β-induced inflammatory and senescence markers, an effect that was counteracted by exogenous SAA2 protein. (G) β-galactosidase and ROS staining demonstrated Vaccarin’s reduction of IL-1β-induced senescence and ROS production in chondrocytes, with SAA2 reversing this effect and enhancing senescence and ROS levels. (H) Relative β-galactosidase positive cells and ROS levels were both quantified. Significance: *p < 0.05; **p < 0.01; NS, non-significance; scale bars: 200 μm (G), 400 μm (H).
    Recombinant Mouse Serum Amyloid A2 Protein Saa2, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/recombinant+mouse+serum+amyloid+a2+protein+saa2/Recombinant+Mouse+Serum+Amyloid+A2+Protein%2C+CF/pm40215820-58-0-20
    Average 93 stars, based on 2 article reviews
    recombinant mouse serum amyloid a2 protein saa2 - by Bioz Stars, 2026-10
    93/100 stars

    Images

    1) Product Images from "Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence."

    Article Title: Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.

    Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology

    doi: 10.1016/j.phymed.2025.156697

    Fig. 4. Vaccarin regulates SAA2 expression through JNK inhibition, reversing IL-1β-induced chondrocyte senescence and inflammation. (A-D) Western blot analysis showing that SP600125 treatment reversed IL-1β-induced inflammation and senescence in chondrocytes, while exogenous SAA2 protein exacerbates these effects and reduced SP600125’s inhibitory effects. (E, F) Western blot confirmed that Vaccarin reduced IL-1β-induced inflammatory and senescence markers, an effect that was counteracted by exogenous SAA2 protein. (G) β-galactosidase and ROS staining demonstrated Vaccarin’s reduction of IL-1β-induced senescence and ROS production in chondrocytes, with SAA2 reversing this effect and enhancing senescence and ROS levels. (H) Relative β-galactosidase positive cells and ROS levels were both quantified. Significance: *p < 0.05; **p < 0.01; NS, non-significance; scale bars: 200 μm (G), 400 μm (H).
    Figure Legend Snippet: Fig. 4. Vaccarin regulates SAA2 expression through JNK inhibition, reversing IL-1β-induced chondrocyte senescence and inflammation. (A-D) Western blot analysis showing that SP600125 treatment reversed IL-1β-induced inflammation and senescence in chondrocytes, while exogenous SAA2 protein exacerbates these effects and reduced SP600125’s inhibitory effects. (E, F) Western blot confirmed that Vaccarin reduced IL-1β-induced inflammatory and senescence markers, an effect that was counteracted by exogenous SAA2 protein. (G) β-galactosidase and ROS staining demonstrated Vaccarin’s reduction of IL-1β-induced senescence and ROS production in chondrocytes, with SAA2 reversing this effect and enhancing senescence and ROS levels. (H) Relative β-galactosidase positive cells and ROS levels were both quantified. Significance: *p < 0.05; **p < 0.01; NS, non-significance; scale bars: 200 μm (G), 400 μm (H).

    Techniques Used: Expressing, Inhibition, Western Blot, Staining

    Fig. 8. Mechanism by which Vaccarin restores mitochondrial function in IL-1β-inhibited chondrocytes by suppressing the JNK-SAA2 signaling pathway, thereby reversing IL-1β-induced inflammation and senescence in chondrocytes.
    Figure Legend Snippet: Fig. 8. Mechanism by which Vaccarin restores mitochondrial function in IL-1β-inhibited chondrocytes by suppressing the JNK-SAA2 signaling pathway, thereby reversing IL-1β-induced inflammation and senescence in chondrocytes.

    Techniques Used:

    Related Articles

    Recombinant:

    Article Title: Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.
    Article Snippet: Recombinant murine interleukin-1β (IL-1β) (RP01340) was obtained from ABclonal (Wuhan, China). .. Recombinant mouse serum amyloid A2 protein (SAA2) (Purity > 85 %, 8478-SA) and Recombinant human IL-1β (201-LB) were purchased from R&D Systems (Minnesota, USA). .. SP600125 (Purity ≥ 99.94 %, S1460) was purchased from Selleck (Texas, USA).



    Similar Products

    recombinant mouse serum amyloid a2 protein saa2  (R&D Systems)
    93
    R&D Systems recombinant mouse serum amyloid a2 protein saa2
    Fig. 4. Vaccarin regulates <t>SAA2</t> expression through JNK inhibition, reversing IL-1β-induced chondrocyte senescence and inflammation. (A-D) Western blot analysis showing that SP600125 treatment reversed IL-1β-induced inflammation and senescence in chondrocytes, while exogenous SAA2 protein exacerbates these effects and reduced SP600125’s inhibitory effects. (E, F) Western blot confirmed that Vaccarin reduced IL-1β-induced inflammatory and senescence markers, an effect that was counteracted by exogenous SAA2 protein. (G) β-galactosidase and ROS staining demonstrated Vaccarin’s reduction of IL-1β-induced senescence and ROS production in chondrocytes, with SAA2 reversing this effect and enhancing senescence and ROS levels. (H) Relative β-galactosidase positive cells and ROS levels were both quantified. Significance: *p < 0.05; **p < 0.01; NS, non-significance; scale bars: 200 μm (G), 400 μm (H).
    Recombinant Mouse Serum Amyloid A2 Protein Saa2, supplied by R&D Systems, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/recombinant+mouse+serum+amyloid+a2+protein+saa2/Recombinant+Mouse+Serum+Amyloid+A2+Protein%2C+CF/pm40215820-58-0-20
    Average 93 stars, based on 1 article reviews
    recombinant mouse serum amyloid a2 protein saa2 - by Bioz Stars, 2026-10
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    Fig. 4. Vaccarin regulates SAA2 expression through JNK inhibition, reversing IL-1β-induced chondrocyte senescence and inflammation. (A-D) Western blot analysis showing that SP600125 treatment reversed IL-1β-induced inflammation and senescence in chondrocytes, while exogenous SAA2 protein exacerbates these effects and reduced SP600125’s inhibitory effects. (E, F) Western blot confirmed that Vaccarin reduced IL-1β-induced inflammatory and senescence markers, an effect that was counteracted by exogenous SAA2 protein. (G) β-galactosidase and ROS staining demonstrated Vaccarin’s reduction of IL-1β-induced senescence and ROS production in chondrocytes, with SAA2 reversing this effect and enhancing senescence and ROS levels. (H) Relative β-galactosidase positive cells and ROS levels were both quantified. Significance: *p < 0.05; **p < 0.01; NS, non-significance; scale bars: 200 μm (G), 400 μm (H).

    Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology

    Article Title: Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.

    doi: 10.1016/j.phymed.2025.156697

    Figure Lengend Snippet: Fig. 4. Vaccarin regulates SAA2 expression through JNK inhibition, reversing IL-1β-induced chondrocyte senescence and inflammation. (A-D) Western blot analysis showing that SP600125 treatment reversed IL-1β-induced inflammation and senescence in chondrocytes, while exogenous SAA2 protein exacerbates these effects and reduced SP600125’s inhibitory effects. (E, F) Western blot confirmed that Vaccarin reduced IL-1β-induced inflammatory and senescence markers, an effect that was counteracted by exogenous SAA2 protein. (G) β-galactosidase and ROS staining demonstrated Vaccarin’s reduction of IL-1β-induced senescence and ROS production in chondrocytes, with SAA2 reversing this effect and enhancing senescence and ROS levels. (H) Relative β-galactosidase positive cells and ROS levels were both quantified. Significance: *p < 0.05; **p < 0.01; NS, non-significance; scale bars: 200 μm (G), 400 μm (H).

    Article Snippet: Recombinant mouse serum amyloid A2 protein (SAA2) (Purity > 85 %, 8478-SA) and Recombinant human IL-1β (201-LB) were purchased from R&D Systems (Minnesota, USA).

    Techniques: Expressing, Inhibition, Western Blot, Staining

    Fig. 8. Mechanism by which Vaccarin restores mitochondrial function in IL-1β-inhibited chondrocytes by suppressing the JNK-SAA2 signaling pathway, thereby reversing IL-1β-induced inflammation and senescence in chondrocytes.

    Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology

    Article Title: Vaccarin ameliorates osteoarthritis by suppressing the c-Jun N-terminal kinase (JNK)-serum amyloid A2 (SAA2) pathway mediating chondrocyte senescence.

    doi: 10.1016/j.phymed.2025.156697

    Figure Lengend Snippet: Fig. 8. Mechanism by which Vaccarin restores mitochondrial function in IL-1β-inhibited chondrocytes by suppressing the JNK-SAA2 signaling pathway, thereby reversing IL-1β-induced inflammation and senescence in chondrocytes.

    Article Snippet: Recombinant mouse serum amyloid A2 protein (SAA2) (Purity > 85 %, 8478-SA) and Recombinant human IL-1β (201-LB) were purchased from R&D Systems (Minnesota, USA).

    Techniques: